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急性运动性轴索型GBS(Acute motor axonal form Guillain-Barre syndrome)的病因与前驱的空肠弯曲菌(Campylobater jejuni,Cj)感染有密切关系,但确切机理仍不十分清楚,我国是GBS病前感染Cj的高发国家,国内急性运动性轴索型GBS(即AMAN型GBS)病人血清显示抗体达峰值期的抗Cj抗体阳性率为91.4％[1]。目前认为Cj感染和体液免疫与AMAN型GBS的发病密切相磁,现将近年来国内外对AMAN型GBS免疫学及免疫发病机制的研究进展作如下综述。1 抗神经节苷脂抗体的研究 1990年,Yuki等[2]提出轴索型GBS与Cj有关,指出Cj的某些LPS与神经纤维的某些神经节苷脂成份相似。Kaida等[3]研究了33例GBS中抗神经节苷脂乙酰半乳糖胺
The etiology of acute motor axonal form of Guillain-Barre syndrome (GBS) is closely related to the infection of Campylobater jejuni (Cj), but the precise mechanism is still unclear. In our country, GBS infection Cj high incidence of countries, the domestic acute motor axonal GBS (ie, AMAN GBS) serum showed anti-Cj antibody peak antibody positive rate of 91.4% [1]. At present, it is thought that Cj infection and humoral immunity are closely phase-magnetized with the onset of AMAN-type GBS. In recent years, the research progress of AMAN-GBS immunology and immune pathogenesis both at home and abroad are summarized as follows. 1 Anti-Ganglioside Antibody Studies In 1990, Yuki et al. [2] proposed that axonal GBS is related to Cj, indicating that certain LPSs of Cj are similar to certain ganglioside components of nerve fibers. Kaida et al [3] studied the anti-ganglioside acetylgalactosamine in 33 GBS