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目的探讨慢性乙型肝炎患者应用聚乙二醇干扰素注射液对听觉系统的影响。方法对60例慢性乙型肝炎患者注射干扰素前后进行听觉检查,包括纯音测听、声导抗测听、镫骨肌声反射等,并与60例健康对照组进行比较。结果慢性乙型肝炎患者干扰素治疗前及治疗3个月比较,在250~4 000 Hz平均听阈及250~2 000Hz倍频纯音听阈的差异无统计学意义(P>0.05);4 000 Hz听阈由治疗前的(16.63±7.71)d B提高至(18.75±8.14)d B,差异有统计学意义(P<0.05)。4例慢性乙型肝炎患者出现听力下降,2例出现耳鸣。结论聚乙二醇干扰素可能引起患者高频听力下降。
Objective To investigate the effect of pegylated interferon injection on auditory system in chronic hepatitis B patients. Methods 60 patients with chronic hepatitis B before and after the injection of interferon auditory examination, including pure tone audiometry, acoustic impedance audiometry, stapes muscle acoustic reflex, and 60 healthy controls were compared. Results There was no significant difference between the mean hearing threshold of 250-4000 Hz and the frequency doubled pure tone audiometry of 250-2000 Hz (P> 0.05) before interferon treatment and 3 months of treatment in patients with chronic hepatitis B. The 4 000 Hz hearing threshold The difference was statistically significant (P <0.05) from (16.63 ± 7.71) d B before treatment to (18.75 ± 8.14) d B before treatment. 4 cases of chronic hepatitis B patients with hearing loss, tinnitus in 2 cases. Conclusion Pegylated interferon may cause high frequency hearing loss in patients.