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泛素-蛋白酶体系统(ubiquitin-proteasome system,UPS)介导的蛋白泛素化降解是调节细胞内蛋白水平及功能的重要途径之一。CUL4是泛素连接酶E3的重要成员,在脊椎动物中存在CUL4A和CUL4B两种亚型,结构高度相似,功能重叠,但并不完全一致。以往对CUL4的研究集中于CUL4A,近年来对CUL4B的研究表明,CUL4B通过UPS参与对蛋白质的调控,在细胞周期调控、基因组稳定、病毒感染、
Ubiquitin-proteasome system (UPS) -mediated protein ubiquitination degradation is one of the important ways to regulate intracellular protein level and function. CUL4 is an important member of ubiquitin ligase E3. There are two subtypes of CUL4A and CUL4B in vertebrates. Their structures are highly similar and overlapped in function, but they are not exactly the same. Previous studies on CUL4 focused on CUL4A. In recent years, studies on CUL4B have shown that CUL4B participates in the regulation of proteins through UPS, and plays an important role in cell cycle regulation, genome stabilization, virus infection,