肥胖症已成为全球性流行病,且发病率正在逐年上升。肥胖可致肾损伤,有文献将出现的蛋白尿、肾小球肥大和硬化称为肥胖相关性肾病(ORG)〔1-2〕。ORG的研究报道近年多见于成年肥胖患者,小儿肥胖致肾损伤程度及脂联素、高胰岛素血症的作用和相互影响文献报道较少。为此,于2006年10 Obesity has become a global epidemic, and the incidence is on the rise. Obesity can cause kidney damage, proteinuria, glomerular hypertrophy and sclerosis that appear in the literature are called obesity-related nephropathy (ORG) [1-2]. ORG research reports more common in recent years in adult obese children, children with obesity caused by renal injury and adiponectin, hyperinsulinemia role and interaction reported in the literature less. To this end, in 2006 10