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目的 探讨宫内环境因素对新生儿胰岛素敏感性的影响。 方法 将入选 2 80例新生儿依据孕周和出生体重分为四组 :足月适于胎龄儿组 133例 ,足月小样儿组 30例 ,早产适于胎龄儿组87例 ,早产小于胎龄儿组 30例。在生后 3d上午哺乳前进行血糖、胰岛素和血脂检测 ,并计算胰岛素与血糖的比值 ,应用SPSS 9.0软件进行统计学处理。 结果 足月小样儿组与足月适于胎龄儿组胰岛素 /血糖比值分别为 1.2 4 3± 0 .70 3和 0 .2 5 9± 0 .837,早产小于胎龄儿组与早产适于胎龄儿组胰岛素 /血糖比值分别为 1.190± 0 .6 83和 0 .4 97± 0 .0 80 ,小于胎龄儿组胰岛素 /血糖比值高于适于胎龄儿组 (P <0 .0 0 1)。足月小样儿组与足月适于胎龄儿组血甘油三酯 (单位 :mmol/L)分别为 2 .399±0 .2 2 3和 1.82 5± 0 .14 1,低密度脂蛋白胆固醇 (单位 :mmol/L)分别为 2 .0 31± 0 .14 0和 1.4 80± 0 .10 4 ,早产小于胎龄儿组与早产适于胎龄儿组血甘油三酯分别为 1.774± 0 .15 9和 1.342± 0 .0 80 ,低密度脂蛋白胆固醇分别为 1.777± 0 .110和 1.336± 0 .0 70 ,小于胎龄儿组血甘油三酯和低密度脂蛋白胆固醇高于适于胎龄儿组 (P <0 .0 0 1)。妊娠高血压综合征 (简称妊高征 )母亲的新生儿胰岛素 /血糖比值平均为 1.0 77± 0 .
Objective To investigate the effect of intrauterine environmental factors on neonatal insulin sensitivity. Methods Two hundred and eighty newborn infants were divided into four groups based on gestational age and birth weight: 133 in term infants, 30 infants in term infants, 87 infants in gestational age group with preterm labor less than 30 cases of gestational age group. Blood glucose, insulin and lipids were tested before breast-feeding on the morning of 3 days after birth, and the ratio of insulin to blood glucose was calculated. SPSS 9.0 software was used for statistical analysis. Results The ratio of insulin to blood glucose in full-moon minipigs and full-term infants with gestational age were 1.2 4 3 ± 0.70 3 and 0. 259 ± 0. 837 respectively, The gestational age group of children with insulin / blood glucose ratio were 1.190 ± 0.63 83 and 0.97 ± 0.80 80, less than gestational age group insulin / blood glucose ratio was higher than the gestational age group (P <0. 0 0 1). Serum triglycerides (units: mmol / L) in full-term minipigs and full-term infants with gestational age were 2.399 ± 0.22 and 1.82 5 ± 0.141, respectively. Low-density lipoprotein cholesterol (Unit: mmol / L) were 2.01 ± 0.14 0 and 1.4 80 ± 0.10 4, preterm birth less than gestational age group and gestational age group preterm gestational blood triglycerides were 1.774 ± 0 .159 and 1.342 ± 0.080, low density lipoprotein cholesterol were 1.777 ± 0.11 and 1.336 ± 0.070, respectively. The levels of serum triglyceride and LDL cholesterol in children younger than gestational age were higher than those in The gestational age group (P <0.001). The average neonatal insulin / glycemic ratio of mothers with pregnancy-induced hypertension (PIH) was 1.077 ± 0.