消化性溃疡是一种慢性复发性疾病,其发生与幽门螺杆菌(HP)的感染有十分密切关系。因此,治疗消化性溃疡一方面需愈合溃疡,另一方面尚需根除伴随的HP感染。1999年2月至12月我院采用泮托拉唑合并阿莫西林治疗HP阳性的消化性溃疡患者65例,均取得了满意效果。 1.临床资料 130例患者均经胃镜证实为消化性溃疡,其中十二指肠溃疡89例,胃溃疡41例,并用快速尿素酶试验及聚合酶联反应(PCR)检查幽门螺杆菌全部为阳性。全组男性91例,女性39例,年龄18～61岁,平均39.6±11.5岁,无心、肝、肺、肾等严重疾病,随机分为泮托拉唑治疗组和雷尼替丁对照组。两组中溃疡数目、大小程度及疼痛等消化道症状与 Peptic ulcer is a chronic recurrent disease, its occurrence and Helicobacter pylori (HP) infection are closely related. Therefore, the treatment of peptic ulcer need to heal ulcers on the one hand, on the other hand need to eradicate accompanying HP infection. From February to December 1999, 65 cases of peptic ulcer patients were treated with pantoprazole and amoxicillin in our hospital, and satisfactory results were obtained. 1. Clinical data 130 patients were confirmed by gastroscopy peptic ulcer, including 89 cases of duodenal ulcer and 41 cases of gastric ulcer, and rapid urease test and polymerase chain reaction (PCR) were all positive for Helicobacter pylori . The whole group of 91 males and 39 females, aged 18 to 61 years old with an average of 39.6 ± 11.5 years of age, without heart, liver, lung, kidney and other serious diseases were randomly divided into pantoprazole treatment group and ranitidine control group. Two groups of ulcer number, size and pain and other gastrointestinal symptoms and