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高亲和力~3H-丙咪嗪结合点是三环类抗抑郁剂的特异性结合点,具有药物受体的性质。该结合点主要存在于5-羟色胺能神经末梢,在解剖和功能上与5-羟色胺的再摄取机制有关。抑郁症的病因和抗抑郁治疗与~3H-丙咪嗪结合点的功能改变密切相关。
High affinity ~ 3H-imipramine binding point is a tricyclic anti-depressant specific binding sites, with the nature of drug receptors. This binding site is mainly found on serotonergic terminals and is anatomically and functionally related to the reuptake mechanism of serotonin. The etiology and antidepressant treatment of depression are closely related to the functional changes of ~ 3H-imipramine binding sites.