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1996年3月14～15日由国际经济信息组织(IBC)在美国华盛顿市召开了《治疗乙型肝炎、丙型肝炎研究的最新进展会议》。现将有关微生物学内容简介如下: 1.DNA疫苗。Davis报道用含乙型肝炎病毒(HBV)PreS/S基因的重组质粒DNA免疫小鼠后,6～17周可产生抗体及T细胞杀伤反应(CTL)。在用HBsAg基因为目的基因的转基因小鼠中,注入上述质粒DNA后,2周后即可测得抗-HBs。8～12周后转基因小鼠产生抗-HBs的效价与正常小鼠相似。其
From March 14 to March 15, 1996, the International Organization for Economic Information and Technology (IBC) convened the “Conference on the Latest Progress in Hepatitis B and Hepatitis C Research” in Washington, DC. Now the microbiology content is as follows: 1. DNA vaccine. Davis reports that antibodies and T cell killing (CTL) can be produced 6 to 17 weeks after mice are immunized with recombinant plasmid DNA containing the PreS / S gene of hepatitis B virus. In transgenic mice that use the HBsAg gene as a target gene, anti-HBs can be detected two weeks after the above plasmid DNA is injected. The potency of anti-HBs in transgenic mice after 8 ~ 12 weeks is similar to that in normal mice. its