宫颈癌是最常见的女性生殖系统肿瘤之一,其发生机制至今尚不清楚。HPV特别是HPV16、18等高危型别感染是引起宫颈癌变的首要因素。但HPV感染并非诱发宫颈癌的唯一因素,尚需与其他因素协同作用,才能导致宫颈恶性病变的发生。临床资料提示,HPV感染与雌激素及其受体在宫颈病变的发 Cervical cancer is one of the most common female reproductive system tumors, the mechanism of which remains unclear. HPV, especially HPV16,18 and other high-risk type infection is the primary factor causing cervical cancer. However, HPV infection is not the only factor inducing cervical cancer, yet need to cooperate with other factors, can lead to the occurrence of cervical malignant lesions. Clinical data suggest that HPV infection and estrogen and its receptors in cervical lesions made