Yanji is the biggest China Korean inhabited city. Based on a newly finished research project, this paper discusses strategic problems about Yanji towards 21st century. The general point of the authors is that at the beginning of new century,Yanji will play a more important role in Tumen River Delta development, regional economy cooperation in Korea Peninsula as well as Northeast Asia, and it will develop to be an important central city in this area. This paper puts forwards Yanji City′s developing goal, urban nature, and urban size, probes its regional orientation, and further probes how to establish The Yanji Urban Economy Cooperation Zone. The authors think that Yanji should depend on its intellect resources and other characteristic resources. Industry development need to pay much attention to modern agriculture, tertiary industry (especially commerce, trade and tourism) and dominant industries, and high-tech industry must give a special care, in order to establish a light industrial structure.