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目的:探讨前列腺增生(benign prostatic hyperplasia,BPH)造成患者膀胱出口梗阻(bladder outletobstruction,BOO)后膀胱逼尿肌中转化生长因子β(transforming growth factor-β,TGF-β)的表达变化。方法:BPH患者54例,分为逼尿肌稳定组(33例)和逼尿肌过度活动(detrusor overactivity,DO)组(21例)。对照组15例为同期在我院因膀胱癌施行开放手术的男性患者,应用免疫组化观察各组逼尿肌中TGF-β的表达。结果:BPH患者包括逼尿肌稳定组与DO组TGF-β的表达水平均明显高于对照组,在对照组、逼尿肌稳定组、DO组之间两两比较差异均有统计学意义(P<0.01)。结论:BPH造成BOO后逼尿肌中TGF-β的表达明显增高,这种变化可能与BOO后膀胱逼尿肌纤维化及DO相关。
Objective: To investigate the expression of transforming growth factor-β (TGF-β) in bladder detrusor after bladder outletobution (BOO) caused by benign prostatic hyperplasia (BPH). Methods: Fifty-four patients with BPH were divided into stable group (33 cases) and detrusor overactivity group (21 cases). Control group of 15 patients for the same period in our hospital for open surgery of bladder cancer in male patients, immunohistochemical observation of the group of detrusor TGF-β expression. Results: The expression of TGF-β in stable group and DO group was significantly higher than that in control group. There were significant differences in the control group, detrusor stabilization group and DO group P <0.01). CONCLUSION: BPH induced a marked increase of TGF-β in detrusor muscle after BOO, which may be related to detrusor fibrosis and DO in BOO.