论文部分内容阅读
前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin/kexin type 9,PCSK9)基因属于前蛋白转化酶(PC)家族,是一个新发现不久的与胆固醇代谢相关基因.近年来,PCSK9在其生物学效应及疾病中的作用越来越受到重视.大量的研究表明,除通过调节低密度脂蛋白受体(LDLR)影响胆固醇代谢外,PCSK9还参与细胞凋亡,促进肝发育、再生,促进神经系统发育,影响神经系统分化并且与炎症过程以及糖尿病相关.本文对PCSK9功能方面最新研究进展进行了综述。
The proprotein convertase subtilisin / kexin type 9 (PCSK9) gene belongs to the pro-proteinase (PC) family and is a newly discovered gene related to cholesterol metabolism.In recent years, Effects and diseases have attracted more and more attention.Many studies have shown that in addition to regulating cholesterol metabolism through the regulation of low density lipoprotein receptor (LDLR), PCSK9 is also involved in apoptosis, promote liver development, regeneration, and promote the nervous system Development, affecting the differentiation of the nervous system and the process of inflammation and diabetes related.In this paper, PCSK9 functional aspects of the latest research progress are reviewed.