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目的 :探讨脑血栓病程与血浆C型利钠多肽 (C -typenatriureticpeptide ,CNP)含量变化之间的关系。方法 :用放射免疫分析法测定了 30例脑血栓患者发病后 1～ 3天、7～ 1 4天、2 1～ 2 8天时的血浆CNP含量。结果 :脑血栓发生后 1～ 3天血浆CNP含量较正常对照组略低 ,但无统计学意义 (P >0 0 5) ,发病后 7～ 1 4天血浆CNP含量较正常对照组明显下降 (P <0 0 1 ) ,发病后 2 1～ 2 8天CNP含量较正常对照组明显升高 (P <0 0 1 ) ,发病后的三组间血浆CNP含量差异显著 (均P <0 0 1 )。结论 :血浆CNP参与了脑血栓发生后不同阶段的病理过程 ,CNP含量的监测可作为动态观察脑血栓病理生理变化的一种手段
Objective: To explore the relationship between the course of cerebral thrombosis and the content of plasma C-type natriuretic peptide (CNP). Methods: Thirty patients with cerebral thrombosis were measured by radioimmunoassay at 1 ~ 3 days, 7 ~ 14 days and 21 ~ 28 days after onset of CNP. Results: The levels of CNP in plasma from 1 to 3 days after cerebral thrombosis were slightly lower than those in normal control group (P> 0.05). The CNP levels in plasma from 7 to 14 days after onset were significantly lower than those in normal control group (P <0.01). CNP levels increased significantly from 21 to 28 days after onset (P <0.01), and were significantly different between the three groups after onset of disease (all P <0.01 ). Conclusion: Plasma CNP is involved in the pathological process at different stages of cerebral thrombosis. The monitoring of CNP level can be used as a means to dynamically observe the pathophysiological changes of cerebral thrombus