论文部分内容阅读
Esmolol盐酸盐是一种超短效、具心脏选择性的β-阻滞剂,推荐用于治疗室上性心动过速、手术期间心动过速和高血压、术后高血压和急性心肌局部缺血。Esmolol极短的半衰期(约9分钟)在治疗危急病人时提供了安全的因素。动物试验表明,esmolol的β-阻滞作用为心得安的1/40,治疗剂量时无内在拟交感活性和明显的膜稳定性。Esmolol主要阻滞心肌的β_1受体,当剂量大于40～100倍时也阻滞支气管和血管肌肉系统。本
Esmolol hydrochloride is an ultra-short acting, cardioselective β-blocker recommended for the treatment of supraventricular tachycardia, tachycardia and hypertension during surgery, postoperative hypertension and acute myocardial infarction Ischemia. The extremely short half-life of Esmolol (approximately 9 minutes) provides a safety factor in the treatment of critically ill patients. Animal experiments show that β-blockade of esmolol is propofol at 1/40 and there is no intrinsic sympathomimetic activity and significant membrane stability at the therapeutic dose. Esmolol mainly blocks β_1 receptors in the myocardium and blocks the bronchial and vascular muscle systems at doses greater than 40 to 100 times. this