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目的 明确仙附、芪地强心口服液治疗心衰的药效作用。方法 用家猫在体心脏建立由戊巴比妥钠诱发的心衰模型 ,观察药物对心衰家猫心功能和血流动力学的影响。结果 仙附、芪地强心口服液和地高辛对戊巴比妥钠诱发家猫心衰具有显著的改善作用 ,治疗后CO、SI、CI都明显增加 (P <0 .0 1) ,而仙附、芪地强心口服液增加幅度大于地高辛对照组 ,且明显增加LVSP、LV -dp/dtmax。对照药巯甲丙脯酸增加CO、CI、SI的作用不如仙附、芪地强心口服液组 ,但不增加心肌负担。结论 仙附、芪地强心口服液明显增加心衰模型心肌收缩力 ,增加心输出量 ,改善外周血液灌注不足 ,从而有效地改善心衰状态。
Objective To clarify the efficacy of Xianfu and Qindi Qiangxin Oral Liquid in treating heart failure. METHODS: The heart failure model induced by sodium pentobarbital was established in the heart of cats in domestic cats, and the effects of drugs on heart function and hemodynamics in heart failure cats were observed. RESULTS: Xianfu, Qidiqiangxin Oral Liquid and digoxin had a significant improvement in heart failure induced by pentobarbital sodium in cats. After treatment, CO, SI, and CI increased significantly (P < 0.01). However, Xianfu and Xindiqiangxin Oral Liquid increased more than Digoxin control group, and LVSP and LV-dp/dtmax were significantly increased. The effect of the increase in CO, CI, and SI was not as high as that of the control group, but the myocardial burden was not increased. Conclusion Xianfu and Qidiqiangxin Oral Liquid can significantly increase myocardial contractility in heart failure model, increase cardiac output and improve perfusion of peripheral blood, which can effectively improve the state of heart failure.