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农药敌枯双的毒性作用和致畸作用,限制了它的广泛使用。国内外对其生物学活性和毒性进行了不少研究。Beaudoin和Scott等(1973)报道,菸酰胺(NAM)与敌枯双(ATDA)同时给药能预防单独给予敌枯双所致胚胎畸形。本文给妊娠小鼠注射ATDA后给予NAM,观察NAM对小鼠致畸的预防作用,着重探讨菸酰胺的给药时间和剂量对预防ATDA致畸的效果有什么影响,为NAM的实际应用研究提供资料。
The toxic effects and teratogenic effects of pesticides double limit its widespread use. At home and abroad on its biological activity and toxicity of a lot of research. Beaudoin and Scott et al. (1973) reported that concurrent administration of nicotinamide (NAM) and azathioprine (ATDA) prevented the embryo deformity caused by rivastigmine alone. In this paper, after injection of ATDA to pregnant mice given NAM to observe the prevention of teratogenicity in mice NAM role, focusing on nicotinamide dosage and dose on the prevention of ATDA teratogenic effects have any effect on the practical application of NAM data.