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目的探讨阿司匹林联合阿托伐他汀对不稳定型心绞痛(UAP)患者血清中白细胞分化抗原40配体(s CD40L)和基质金属蛋白酶-2(MMP-2)的影响。方法将92例UAP患者随机分为对照组(n=46)和观察组(n=46)。2组患者均在常规药物的治疗基础上,对照组加用阿司匹林(100 mg/d,早餐后顿服),观察组在对照组的基础上加用阿托伐他汀(10 mg/次,每晚1次)。疗程均为4周,测定两组患者治疗前后血清s CD40L和MMP-2水平,并观察心绞痛疗效、治疗前后血脂水平。结果对照组治疗总有效率为67.39%,明显低于观察组的86.96%,差异有统计学意义(P<0.05)。两组治疗后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白C(LDL-C)、s CD40L和MMP-2水平均较治疗前显著降低,差异均有统计学意义(P<0.05),且治疗后观察组上述指标水平均明显低于对照组,差异有统计学意义(P<0.05)。结论阿司匹林联合阿托伐他汀可改善UAP的临床症状,可能与通过降低患者血清中s CD40L和MMP-2浓度,以及血脂的水平有关。
Objective To investigate the effects of aspirin combined with atorvastatin on serum sCD40L and MMP-2 in patients with unstable angina pectoris (UAP). Methods 92 patients with UAP were randomly divided into control group (n = 46) and observation group (n = 46). The patients in both groups were treated with conventional drugs. The control group was given aspirin (100 mg / d, after breakfast), and the observation group was given atorvastatin (10 mg / Night 1 time). The course of treatment was 4 weeks. Serum levels of sCD40L and MMP-2 were measured before and after treatment in both groups. The angina pectoris efficacy and blood lipid level before and after treatment were observed. Results The total effective rate of the control group was 67.39%, which was significantly lower than that of the observation group (86.96%), the difference was statistically significant (P <0.05). The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein C (LDL-C), sCD40L and MMP-2 in the two groups after treatment were significantly lower than those before treatment, with significant differences P <0.05), and after treatment, the above indicators in the observation group were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusions Aspirin combined with atorvastatin can improve the clinical symptoms of UAP, which may be related to the decrease of serum s-CD40L and MMP-2 levels and the level of blood lipids in patients.