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[目的]探讨肾衰灌肠方对慢性肾功能衰竭(CRF)失代偿期患者贫血、毒素清除及生活质量的影响.[方法]94例CRF失代偿期患者随机分为两组,对照组给予常规治疗,观察组在常规治疗基础上给予肾衰灌肠方治疗2周.比较两组灌肠前后疗效、贫血、毒素清除和生活质量.[结果]观察组治疗总有效率为91.19％(43/47),高于对照组74.47％(35/47),且差异有显著性(P＜0.05);治疗后两组血红蛋白、红细胞计数、白细胞计数均显著上升,且观察组上升幅度显著大于对照组(P＜0.05);观察组贫血改善率为93.02％(40/43),高于对照组76.19％(32/42)(P＜0.05);治疗后两组血清肌酐、血尿酸、血尿素氮、血磷和血磷和血清胱抑素水平均显著下降(P＜0.05),生活质量评分显著上升(P＜0.05),且观察组上升幅度显著高于对照组(P＜0.05).[结论]肾衰灌肠方可显著改善CRF失代偿期患者症候表现,改善贫血症状,提高肾脏毒素清除率和患者生活质量.“,”[Objective]To explore the effect of Shenshuai enema(renal failure enema)on anemia,toxin removal and quality of life in patients with chronic renal failure(CRF)in decompensated stage.[Methods]A total of 94 patients with CRF in the decompensated stage were randomly divided into two groups,with 47 ca-ses in each group.The control group was given conventional therapy,and the enema group received Shenshuai enema treatment for two weeks on the basis of conventional therapy.The therapeutic effect,anemia,toxin clearance and quality of life were compared between the two groups.[Results]The total effective rate in the en-ema group was significantly higher than that in the control group(91.19％vs 74.47％);the difference was statistically significant(P ＜0.05).After treatment,the levels of hemoglobin,red blood cell count and white blood cell count increased significantly in the two groups,the values in the enema group increased more signifi-cantly than those in the control group(P ＜0.05).The anemia improvement rate in enema group was 93.02％(40/43),which was significantly higher than that in the control group 76.19％(32/42)(P ＜0.05).After treatment,the levels of serum creatinine,blood uric acid,blood urea nitrogen,serum phosphorus and serum cystatin decreased significantly.The quality of life scores also increased significantly(P ＜0.05).The changes in the enema group were more significant than those in the control group(P ＜0.05).[Conclusion]Renal fail-ure enema can significantly relieve the symptoms and anemia,improve renal toxin clearance rate and the quali-ty of life in patients with CRF.