采用多指示剂稀释曲线动态观察犬油酸型呼吸窘迫综合征（ＲＤＳ）模型的肺泡毛细血管通透性、血管外肺水和心输出量，并与相应时间的血气、Ｘ线胸片及病理组织学检查进行对比。结果表明：实验犬注入油酸后肺泡毛细血管的通透性立即明显增高，且发生时间明显早于血管外肺水、血气和胸片的改变，与ＲＤＳ的早期病理改变相对应。作者认为：测定肺泡毛细血管通透性有可能作为一种诊断ＲＤＳ的早期敏感指标 The multi-indicator dilution curve was used to observe the alveolar capillaries permeability, extra-pulmonary water and cardiac output in dogs with oleic acid-induced respiratory distress syndrome (RDS) model. The blood gas, X-ray and pathology Histological examination for comparison. The results showed that the permeability of alveolar capillaries immediately after oleic acid injection in experimental dogs was significantly increased, and the onset time was significantly earlier than that of extravascular extracorporeal pulmonary water, blood gas and chest radiograph, corresponding to the early pathological changes of RDS. The authors believe that the determination of alveolar capillary permeability may be used as a sensitive early diagnosis of RDS indicators