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本研究以日本大耳白兔建立实验性动脉粥样硬化模型，每天灌胃猪油１０ｇ，胆固醇１ｇ，４０ｄ后主动脉内在出现大片的粥样化斑块，切片镜检内皮细胞增生大量泡沫细胞聚积，内膜显著增厚呈典型粥样化病理改变，同时发现血脂和ＬＰＯ极度升高，ＳＯＤ活性明显降低，表明高脂血症和脂质过氧化损伤在引起动脉粥样梗化过程中是重要的因素。实验组动物每天灌胃猪油、胆固醇同时加灌刺梨汁１０ｍｌ，４０ｄ后，主动脉内膜仅有散在的点状粥样化斑块，切片病理改变较微，并可大幅度降低血脂和ＬＰＯ水平，提高ＳＯＤ活性，表明刺梨可能通过降低血脂质化氧化损伤防止动脉内膜粥样化斑块的形式。
In this study, Japanese albino rabbits were established experimental atherosclerosis model, daily lard lorg 10g, cholesterol 1g, 40d after the aorta appeared large atherosclerotic plaques, microscopic examination of endothelial cell proliferation foam cells Accumulation, thickening of the intima was typical of atherosclerotic pathological changes. At the same time, it was found that blood lipids and LPO were extremely elevated and SOD activity was significantly reduced, indicating that hyperlipidemia and lipid peroxidation injury are the processes that cause atherosclerosis. Important factor. Animals in the experimental group were treated with lard and cholesterol at the same time and 10 ml of pear juice was added. After 40 days, there was only scattered atherosclerotic plaques in the aortic intima. The pathological changes of the sections were slight, and the lipids were significantly reduced. LPO levels, which increase SOD activity, suggest that Rosa roxburghii may prevent the formation of arterial intimal atheroma plaques by reducing lipid oxidation damage.