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目的:探讨黄金胶囊对2型糖尿病(T2DM)大鼠胰岛素抵抗(IR)的影响,并初步探讨其作用机制。方法:采用给大鼠腹腔一次性注射小剂量链脲佐菌素(STZ),并加饲高热量饮食(富含脂肪和蔗糖),制备T2DM伴IR大鼠模型,观察黄金胶囊对糖尿病大鼠体重、血糖、血清总胆固醇(TC),甘油三酯(TG),高密度脂蛋白-胆固醇(HDL-C),血清胰岛素和胰岛素敏感性指数的影响。结果:黄金胶囊能降低T2DM伴IR模型大鼠空腹血糖具体剂量;黄金胶囊能降低病鼠血清TC,TG的水平,并提高HDL-C的水平,黄金胶囊能降低病鼠高胰岛素血症,提高了胰岛素敏感性指数;实验中未发现明显的不良反应。结论:黄金胶囊对T2DM伴IR大鼠有降血糖,调节脂代谢紊乱及改善其IR的作用。
Objective: To investigate the effect of gold capsule on insulin resistance (IR) in type 2 diabetes mellitus (T2DM) rats and to explore its mechanism. Methods: A single dose of streptozotocin (STZ) was intraperitoneally injected into the abdominal cavity of rats and fed with high caloric diet (rich in fat and sucrose) to prepare T2DM model with IR. The effects of Huangjin capsule on diabetic rats Body weight, blood glucose, serum total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), serum insulin and insulin sensitivity index. Results: Golden Capsule can reduce the specific dose of fasting blood glucose in T2DM rats with IR model; Golden Capsule can reduce serum TC, TG levels and increase the level of HDL-C in rats, and Golden Capsule can reduce the hyperinsulinemia Insulin sensitivity index; no obvious adverse reactions were found in the experiment. Conclusion: Golden Capsule on T2DM with IR rats hypoglycemic, lipid metabolism disorder and improve its IR effect.