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目的:了解甘肃省出生缺陷的发生率、病种及顺位,为“甘肃省出生缺陷干预工程”项目的实施提供基线资料。方法:根据甘肃省地理特点及经济状况,按随机分层整群抽样方法,抽取了4个县的40个乡为调查点。以调查点2001年1月1日-2002年1月1日出生的婴儿为调查对象(包括死产、活产)。由受过统一培训的调查员从县、乡医院、计划生育服务站、妇幼保健站、私人诊所及接生员处获取初级资料,进一步入户调查婴儿出生的情况并填写出生缺陷登记表。出生缺陷病种以医院诊断为准。结果:甘肃省出生缺陷率为16.4‰,出生缺陷病种顺位依次为:神经管畸形7.07％0、低出生体重儿4.98％、四肢畸形2.09％0、唇腭裂O.80‰、唐氏综合征0.48％0。出生缺陷儿中男性18.55％0,女性13.9％0,不同县出生缺陷病种顺位不同。出生缺陷病死率为47.06％,归因出生缺陷死亡比为49.0％。结论:甘肃省出生缺陷发生率在全国属较高地区之一。
OBJECTIVE: To understand the incidence, prevalence and prevalence of birth defects in Gansu Province and provide baseline data for the implementation of Gansu Provincial Birth Defects Intervention Project. Methods: According to the geographical characteristics and economic status of Gansu Province, 40 strata of 4 counties were selected as the survey points by randomly stratified cluster sampling method. The babies born at the investigation point from January 1, 2001 to January 1, 2002 were surveyed (including stillbirth and live birth). First-class information is obtained from county and township hospitals, family planning service stations, maternal and child health stations, private clinics and midwives by uniformly trained investigators, further household surveys of infants born and registration of birth defects. Birth defects in hospital diagnosis prevail. Results: The birth defect rate was 16.4 ‰ in Gansu province. The order of birth defects was 7.07% of neural tube defects, 4.98% of low birth weight children, 2.09% of limb deformities, O.80 ‰ of cleft lip and palate, Sign 0.48% 0. Birth defects in children male 18.55% 0, female 13.9% 0, birth defects in different counties in different order. The fatality rate of birth defects was 47.06%, and the death rate attributable to birth defects was 49.0%. Conclusions: The incidence of birth defects in Gansu Province is one of the highest in China.