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目的:研究颊粘膜鳞癌细胞凋亡发生情况,并分析其与临床病理特征及预后的关系。方法:采用末端脱氧核苷酰转移酶介导的dUTP缺口末端标记(TUNEL)法检测凋亡细胞,计算凋亡指数。结果:本组34例颊癌标本均有凋亡细胞发生,凋亡指数范围为0.12～0.92,均值0.38,凋亡指数与病理学分级之间有关(P<0.01),而与临床分期及颈淋巴结转移无统计学意义(P>0.05);生存率单因素分析未能揭示凋亡指数高低影响颊癌预后(P>0.05)。结论:颊癌细胞凋亡的发生与分化恶性程度有关,但凋亡指数不能作为颊癌的预后指标
Objective: To investigate the apoptosis of buccal mucosal squamous cell carcinoma and to analyze its relationship with clinicopathological features and prognosis. Methods: Apoptotic cells were detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL), and the apoptosis index was calculated. Results: Apoptotic cells were found in all 34 specimens of buccal carcinoma. The apoptotic index ranged from 0.12 to 0.92, with an average of 0.38. The apoptosis index was correlated with pathological grade (P <0.01), but not with clinical stage and neck There was no significant difference in lymph node metastasis (P> 0.05). Univariate analysis of survival rate failed to reveal the prognosis of buccal carcinoma (P> 0.05). Conclusion: The apoptosis of buccal carcinoma is related to the degree of differentiation malignancy, but the apoptosis index can not be used as prognostic indicator of buccal carcinoma