视黄酸(RA)是维生素A的代谢产物,在胚胎发育中起着重要的作用,对RA信号的研究已经成为发育生物学研究领域的热点之一。心脏发育过程中,主要包括:心脏原基的出现、心管形成、左右不对称发育、心脏环化、腔室形成、内流系统形成及传导系统发生等阶段。本文从心脏不同发育阶段着手,综述了国内外对RA信号影响心脏发育的最新研究进展,为先天性心脏病的防治提供线索。 Retinoic acid (RA) is a metabolite of vitamin A and plays an important role in embryonic development. The study of RA signal has become one of the hot spots in the field of developmental biology. Cardiac development, including: the emergence of cardiac primordial, cardiac tube formation, asymmetric development around the heart, circulatory heart, chamber formation, influx system formation and conduction system occurs stage. This article starts from different stages of heart development, summarizes the latest research progress on the influence of RA signal on heart development at home and abroad, and provides clues for the prevention and treatment of congenital heart disease.