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目的探讨柯萨奇病毒(COX)感染与小儿过敏性紫癜(HSP)发病的关系。方法应用酶联免疫吸附测定(ELISA)法检测30例HSP患儿及32例上呼吸道感染患儿血液中COX及其速率法测定心肌酶谱。结果 (1)HSP患者COX阳性14例(46.7%),上呼吸道感染患者COX阳性7例(21.9%),比较差异有统计学意义(P<0.05);(2)过敏性紫癜组中COX感染患儿与无COX感染患儿心肌酶谱[肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)]差异有统计学意义(P<0.05);(3)HSP组COX阳性患儿中HSPN(HSP肾炎)与非HSPN心肌酶谱差异无统计学意义(P>0.05)。结论 COX感染率与小儿HSP发病率两者有相关性,可能是HSP发病重要诱因之一,HSP患儿心肌酶谱异常可能与COX病毒感染有一定关系。
Objective To investigate the relationship between coxsackievirus (COX) infection and the incidence of Henoch-Schonlein purpura (HSP) in children. Methods Enzyme linked immunosorbent assay (ELISA) was used to detect the myocardial COX in 30 HSP children and 32 children with upper respiratory tract infection. Results (1) 14 cases (46.7%) were positive for COX in HSP patients and 7 cases (21.9%) were positive for COX in upper respiratory tract infections patients, the difference was statistically significant (P <0.05); (2) COX infection in allergic purpura There were significant differences in myocardial enzyme profiles [creatine kinase (CK-MB) and lactate dehydrogenase (LDH)] in children with and without COX infection (P <0.05); (3) HSPN (HSP nephritis) and non-HSPN myocardial enzymes in children with no significant difference (P> 0.05). Conclusions There is a correlation between the infection rate of COX and the incidence of HSP in children, which may be one of the important inducing factors of HSP. The abnormal myocardial enzymes in children with HSP may be related to the infection of COX virus.