能够无创定量测量人体组织弹性模量的声辐射力脉冲超声弹性成像方法,已经逐渐成为进行肝硬化分期和乳腺癌良恶性判别等临床诊断的重要工具。但是,在临床实践中也发现,弹性模量测量的稳定性会受到测量深度和组织各向异性等多种因素的影响。因此,如何通过算法的改进提高声辐射力脉冲超声弹性成像测量结果的可靠性,一直是该领域所关注的重要课题之一。文章对现有的基于拉东变换的剪切波速度估计算法进行了多种方式的改进,并利用自主研发的声辐射力定量超声弹性成像系统所采集的超声射频数据,对几种方法得出的剪切波速度测量结果进行了比较。这些改进算法可以被分为两类:(I)在以“时间-侧向位置”为坐标的位移矩阵上进行拉东变换;(II)在以“时间-深度”为坐标的位移矩阵上进拉东变换。第一类算法试图找到在某一个特定深度上剪切波侧向传播的最佳拟合轨迹,而第二类算法则试图直接找到在整个测量深度范围内,剪切波波前通过每个侧向位置的准确时间点。文章在标准弹性仿体和离体猪肉组织样本上进行了测量实验,比较了在不同深度位置上重复测量结果的可靠性,以及这些算法的耗时情况。实验结果将有助于我们找到一种兼顾测量稳定性和计算速度的新型剪切波速度估计算法,并将其应用到声辐射力脉冲超声弹性成像中,提高其测量结果的可靠性和在临床应用中的价值。 The method of noninvasive and quantitative measurement of elasticity of human tissue with ultrasonic radiation has been gradually becoming an important tool for clinical diagnosis of staging of liver cirrhosis and benign and malignant breast cancer. However, it is also found in clinical practice that the stability of elastic modulus measurement is affected by many factors such as the depth of measurement and the anisotropy of tissue. Therefore, how to improve the reliability of pulsed ultrasound elastography measurement results through the improvement of the algorithm has been one of the important topics in this field. In this paper, several improvements have been made to the existing shear wave velocity estimation algorithm based on the Radon transform, and the ultrasonic radiofrequency data collected by the ultrasonic elastography system has been quantified using the self-developed sound radiation force. The shear wave velocity measurements were compared. These improved algorithms can be divided into two categories: (1) Radon transformation on a displacement matrix with “Time-Lateral Position” as coordinate; (II) Radon transformation with “Time-Depth” Displacement Matrix Upward Radon Transform. The first kind of algorithm tries to find the best fitting trajectory of lateral propagation of shear waves at a certain depth, while the second kind of algorithm tries to find directly in the whole measurement depth range. The shear wave front passes through each side The exact point in time to the location. The article has carried on the measurement experiment on the standard elastic imitation body and the in vitro pork tissue sample, compared the reliability of the repeated measurement result in the different depth positions, and the time-consuming situation of these algorithms. The experimental results will help us to find a new shear wave velocity estimation algorithm that takes into account the measurement stability and computational speed, and apply it to the acoustic radiation pulsed ultrasound elastography to improve the reliability of the measurement results and clinical application The value of the application.