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研究金银花(FlosLonicerae,FL)及与茵陈蒿混合煎液对血糖和血脂的作用和作用机制。以正常防治性给药、糖尿病(DM)和高脂模型小鼠探讨FL及与茵陈蒿(金-茵)合剂的作用。结果表明,FL及金-茵合剂能抑制四氧嘧啶(ALX)致小鼠血糖升高作用;但对正常、DM和高脂小鼠血糖未见明显影响。FL及金-茵合剂能降低上述模型小鼠血清胆固醇(TC)及动脉粥样硬化指数(AI),提高高密度脂蛋白-胆固醇(HDL-C)含量。提示FL、金-茵合剂能对抗ALX对胰腺β细胞的损伤,并能调节内、外源性血脂代谢紊乱
To study the effect and mechanism of honeysuckle (FlosLonicerae, FL) and mixed decoction of Artemisia capillaries on blood glucose and blood lipids. The effects of FL and Artemisia capillaris (Jin-Yin) mixture were investigated in normal control, diabetic (DM) and high-fat model mice. The results showed that FL and Jin-Yin mixture can inhibit the elevation of blood glucose in mice induced by alloxan (ALX); however, no significant effect on blood glucose was observed in normal, DM, and high-fat mice. FL and Jin-Yin mixture can reduce the serum cholesterol (TC) and atherosclerosis index (AI) of the above model mice, and increase the high density lipoprotein-cholesterol (HDL-C) content. It is suggested that FL and Jin-Yin mixture can counteract the damage of ALX to pancreatic βcells and regulate the metabolism of internal and exogenous lipids.