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目的比较埃索美拉唑与奥美拉唑治疗幽门螺杆菌(Hp)阳性十二指肠球部溃疡的临床疗效。方法将132例Hp阳性十二指肠溃疡患者随机分为试验组和对照组。在常规治疗基础上,试验组给予埃索美拉唑联合阿莫西林和克拉霉素,对照组给予奥美拉唑联合阿莫西林和克拉霉素对患者实施Hp根除治疗。比较2组患者的临床疗效、Hp根除率及不良反应。结果试验组治疗总有效率、Hp根除率高于对照组,不良反应发生率低于对照组,差异均有统计学意义(P<0.05)。结论对Hp阳性十二指肠球部溃疡患者采用埃索美拉唑三联疗法治疗有更为显著地治疗效果,埃索美拉唑具有较高的临床应用价值,值得推广应用。
Objective To compare the clinical efficacy of esomeprazole and omeprazole in the treatment of Helicobacter pylori (Hp) -positive duodenal ulcer. Methods 132 cases of Hp-positive duodenal ulcer patients were randomly divided into experimental group and control group. On the basis of routine treatment, the test group was given esomeprazole combined with amoxicillin and clarithromycin, the control group was given omeprazole combined with amoxicillin and clarithromycin in patients with Hp eradication therapy. The clinical efficacy, Hp eradication rate and adverse reactions in two groups were compared. Results The total effective rate of the treatment group, Hp eradication rate higher than the control group, the incidence of adverse reactions was lower than the control group, the difference was statistically significant (P <0.05). Conclusion The treatment of Hp-positive duodenal ulcer patients with esomeprazole triple therapy has a more significant therapeutic effect, esomeprazole has a high clinical value, it is worth promoting the application.