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目的分析急性早幼粒细胞性白血病并发中枢神经系统白血病的临床特点。方法选择2012年9月—2014年8月,来我院治疗急性早幼粒细胞性白血病并发中枢神经系统白血病的患者11例作为观察组,选择69例同期单纯患急性早幼粒细胞性白血病的患者作为对照组,观察2组患者的各项指标情况。结果观察组患者的白细胞计数水平明显高于对照组,血小板计数水平明显低于对照组,复发率明显高于对照组,差异均有统计学意义(P<0.05)。结论急性早幼粒细胞性白血病并发中枢神经系统白血病患者的白细胞计数水平较高,血小板计数水平较低,复发率较高;提高药物治疗效果及用药安全性,能有效减少病死率、延长患者生存期。
Objective To analyze the clinical features of acute promyelocytic leukemia complicated with central nervous system leukemia. Methods Seventy patients with acute promyelocytic leukemia complicated with central nervous system leukemia in our hospital from September 2012 to August 2014 were selected as the observation group and 69 patients with acute promyelocytic leukemia Patients as a control group, the two groups of patients were observed indicators of the situation. Results The level of leukocyte in the observation group was significantly higher than that in the control group, and the platelet count was significantly lower than that in the control group. The recurrence rate was significantly higher than that in the control group (P <0.05). Conclusions Patients with acute promyelocytic leukemia complicated with central nervous system leukemia have higher level of white blood cell count, lower platelet count and higher recurrence rate. Improving drug treatment and medication safety can effectively reduce mortality and extend patient survival period.