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目的 分析婴儿巨细胞病毒 (CMV)肝炎的临床特征及观察更昔洛韦的治疗效果。方法 ①回顾性分析 12 1例婴儿CMV肝炎的临床特征。②观察更昔洛韦正规治疗的 5 3例婴儿CMV肝炎治疗前后血清总胆红素水平、肝脾大小、肝酶 (ALT、AKP、γ GT)变化 ,定量检测 (FQ PCR法 )尿CMV DNA ,同时观察药物不良反应。结果 婴儿CMV肝炎绝大部分以黄疸为首发表现就诊 (90 9% ) ,但亦有以其他不典型症状就诊者。多伴有肝脾肿大 (96 7%和 49 6 % ) ,先天性感染者易合并先天畸形 (39 7% )。病程中可并发机会致病菌败血症、呼吸道感染、血液系统受累、维生素K缺乏等。应用更昔洛韦 5mg/kg每 12h静滴 1次 ,用 (14± 2 )d后 ,血清胆红素下降、肝脾回缩、血清ALT降低、尿CMV DNA定量减少 ,所有指标均差异显著 (P <0 0 1)。未见更昔洛韦的明显副作用。结论 对以黄疸为首发症状就诊的患儿应警惕CMV肝炎的发生 ,治疗中除应用特异抗病毒药物外应同时进行抗细菌、预防出血治疗。并加强母孕期监测及保健。更昔洛韦 5mg/kg每 12h用 1次静滴治疗 ,安全、有效、副作用小 ,值得推广。
Objective To analyze the clinical features of infant cytomegalovirus (CMV) hepatitis and observe the curative effect of ganciclovir. Methods ① The clinical features of 12 cases of infant CMV hepatitis were analyzed retrospectively. ② The levels of serum total bilirubin, liver and spleen, liver enzymes (ALT, AKP, γGT) were measured before and after treatment of 53 infants with ganciclovir, and quantitatively detected by FQ PCR. , While observing adverse drug reactions. Results The majority of infants with CMV hepatitis presented in jaundice (90.9%), but other atypical symptoms were also seen. Mostly accompanied by hepatosplenomegaly (96.7% and 49.6%), congenital infections were easily complicated by congenital malformations (39.7%). Pathogenesis may be opportunistic pathogens sepsis, respiratory infections, blood system involvement, vitamin K deficiency and so on. Application of ganciclovir 5mg / kg intravenously once every 12h, with (14 ± 2) d, decreased serum bilirubin, liver and spleen retraction, decreased serum ALT, urine CMV DNA quantitative reduction of all indicators were significantly different (P <0 0 1). No obvious side effects of ganciclovir. Conclusions Children with jaundice as the first symptom should be alert to the occurrence of CMV hepatitis. In addition to the application of specific antiviral drugs, anti-bacterial and hemorrhage prevention should be performed simultaneously. And strengthen monitoring during pregnancy and health care. Ganciclovir 5mg / kg every 12h with an intravenous infusion of safe, effective, small side effects, it is worth promoting.