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第Ⅳ类为钙阻滞剂。其主要作用为:①阻滞细胞膜钙离子内流的通道,使细膜内缺钙而抑制心肌收缩;②窦房结和房室结慢反应细胞的钙离子内流受阻,减低动作电位4位相坡度,抑制其自律性;③抑制0位相除极速度和振幅,延长房室结的不应期;④扩张冠状动脉及周围血管。常用的药物为异搏停(Verapamil,异搏定 Isoptine,又称戊脉安)。其他钙拮抗剂如心痛定(硝苯吡啶Nifedipine)、硫氮(艹卓)酮(Deiltiazem),这两种药物目前尚未发现其有抗心律失常的作用。
The fourth category is calcium blockers. Its main role is: ① block cell membrane calcium influx of channels, so that the thin film of calcium and inhibit myocardial contraction; ② sinus node and atrioventricular node slow calcium influx blocked cells, reducing the action potential 4 phase Slope, inhibit their self-discipline; ③ inhibit the zero-phase division of the speed and amplitude, to extend the refractory period of atrioventricular node; ④ dilation of the coronary arteries and peripheral blood vessels. Commonly used drugs for verapamil (Verapamil, verapamil Isoptine, also known as verapamil). Other calcium antagonists such as nifedipine and deiltiazem have not been found to have anti-arrhythmic effects.