论文部分内容阅读
以盐酸二甲双胍为模板分子、Fe_3O_4为磁核、α-甲基丙烯酸为功能单体、乙二醇二甲基丙烯酸酯为交联剂、偶氮二异丁腈为引发剂,采用表面印迹聚合法成功制备了对盐酸二甲双胍具有特异性识别功能的磁性分子印迹聚合微球。合成的磁性聚合物具有良好的磁响应,在外加磁场下可实现快速磁分离。红外光谱、X射线光电子能谱和扫描电镜结果证实聚合物为核壳结构,磁性粒子由硅烷偶联剂完全包覆,并在其表面形成了一层分子印记聚合物。静态吸附实验结果表明,制备的磁性分子印迹聚合物对模板分子盐酸二甲双胍具有良好的吸附能力,其饱和吸附量为83mmol/kg。以双胍类降糖成分盐酸丁二胍和盐酸苯乙双胍为竞争分子,磁性印迹聚合物对模板分子表现出良好的特异选择性。
Using metformin hydrochloride as template, Fe_3O_4 as magnetic core, α-methacrylic acid as functional monomer, ethylene glycol dimethacrylate as crosslinking agent and azobisisobutyronitrile as initiator, Magnetic molecularly imprinted polymer microspheres with specific recognition of metformin hydrochloride were successfully prepared. Synthetic magnetic polymer has a good magnetic response, in the applied magnetic field can achieve rapid magnetic separation. The results of FT-IR, X-ray photoelectron spectroscopy and scanning electron microscopy confirmed that the polymer was a core-shell structure. The magnetic particles were fully coated with a silane coupling agent and formed a molecularly imprinted polymer on the surface. The results of static adsorption experiment show that the prepared molecularly imprinted polymer has a good adsorption capacity for the template molecule metformin hydrochloride with a saturated adsorption capacity of 83 mmol / kg. Using the biguanide hypoglycemic agents buformin hydrochloride and phenformin hydrochloride as competitive molecules, the magnetic imprinted polymers showed good specific selectivity for template molecules.