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在氯化锌和氯化胆碱组成的深共融溶剂中,以芳香醛、硝基甲烷和N-取代苯胺为原料,建立了一种绿色的亨利-傅克烷基化串联反应方法.在该方法中,醛先与硝基甲烷发生Henry反应,其产物再与富电子芳烃进行Friedel-Crafts烷基化反应.该一锅法串联反应不需要额外添加催化剂,在温和条件下就能以较高产率快速地合成一系列目标产物.深共熔溶剂(氯化锌和氯化胆碱)廉价,且可循环使用,从而降低了合成成本.“,”A green multicomponent reaction between aldehydes,nitromethane and N-substituted anilines in deep eutectic solvent(DES)has been developed.In this reaction,aldehydes and nitromethane underwent Henry reaction,followed by a Friedel-Crafts alkylation reaction with electron-rich arenes.The desired products were formed quickly in excellent yields under mild conditions without the need of any additional catalysts.The deep eutectic solvent(zinc chloride and choline chloride)is cheap and recyclable,which reduces the synthesis cost.