Livin是凋亡抑制蛋白家族的成员之一,其在多种生物中广泛存在,在大多数正常成人组织中不表达或低表达,但在一些恶性肿瘤组织中呈高表达,在调节细胞分裂、细胞周期与信号转导中起重要作用,与肿瘤的发生、发展密切相关,被认为是一些肿瘤不良预后的独立指标,并可能为肿瘤的早期诊断、临床靶向治疗提供新方向。 Livin, a member of the apoptosis-inhibitory protein family, is widespread in a wide range of organisms and is not expressed or under-expressed in most normal adult tissues but highly expressed in some malignant tumor tissues. In the regulation of cell division, It plays an important role in cell cycle and signal transduction and is closely related to tumorigenesis and development. It is considered as an independent index of some poor prognosis of tumor, and may provide a new direction for early diagnosis and clinical targeted therapy of tumor.