许多肝脏疾病的发生、发展与自身免疫反应有关,血清中常出现多种自身抗体。1965年Walker等发现原发性胆汁性肝硬化(PBC)患者血中存在抗线粒体抗体。同年Johnson应用免疫荧光间接法在狼疮样肝炎患者血中检查出抗平滑肌抗体。1972年Me-yer zum Buschenfelde报道,他在60年代从人肝细胞匀浆中提取出一种肝特异性抗原,肝特异性脂蛋白(LSP),它在自身免疫性疾病的发生中有重要意义。1979年他又 Many liver diseases, development and autoimmune reactions, serum often appear a variety of autoantibodies. In 1965, Walker et al found that anti-mitochondrial antibodies were present in the blood of patients with primary biliary cirrhosis (PBC). In the same year Johnson applied immunofluorescence indirect method to detect anti-smooth muscle antibodies in the blood of patients with lupus-like hepatitis. In 1972, Meyerzum Buschenfelde reported that in the 1960s he extracted a liver-specific antigen, liver-specific lipoprotein (LSP) from human hepatocyte homogenates, which is of great importance in the development of autoimmune diseases . In 1979 he again