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为观察补充锌剂对学龄前儿童体内锌水平以及细胞免疫功能的影响 ,对143名学龄前儿童进行了为期6个月的对照观察 ,其中补锌组88名 ,对照组55名。每天补充10mg元素锌。6个月后 ,补锌组儿童的血清锌浓度从12.8μmol/L±1.87μmol/L提高到15.4μmol/L±1.68μmol/L(P<0.01) ;并明显高于对照组14.4μmol/L±1.20μmol/L(P<0.01) ;此外 ,对其中血清锌浓度低下的40名儿童 ,补锌组25名 ,对照组15名 ,用流式细胞技术分析补充锌剂前后T细胞亚群的变化 ,结果显示补锌组儿童的CD4 +细胞从37.3 %±4.54%上升到39.6 %±3.36 %(P<0.01),CD8 +细胞从26.7 %±5.07 %上升到28.2 %±4.66 %(P<0.01)。表明小剂量补充锌剂能改善儿童的锌营养状况及免疫功能 ,可能有助于减少感染性疾病的发生
In order to observe the effect of zinc supplementation on the levels of zinc and cellular immune function in pre-school children, 143 pre-school children were enrolled in this study for 6 months. 88 of them were in the zinc-supplementing group and 55 in the control group. Daily supplement of 10mg elemental zinc. After 6 months, the level of serum zinc in children with zinc supplementation increased from 12.8μmol / L ± 1.87μmol / L to 15.4μmol / L ± 1.68μmol / L (P <0.01), and was significantly higher than that in control group (14.4μmol / L ± 1.20 μmol / L (P <0.01). In addition, 40 children with low serum zinc concentration, 25 zinc supplementation groups and 15 control groups were included in this study. Flow cytometry was used to analyze the changes of T lymphocyte subsets (P <0.01). The percentage of CD8 + cells increased from 26.7% ± 5.07% to 28.2% ± 4.66% (P <0.01), and the percentage of CD4 + cells increased from 37.3% ± 4.54% to 39.6% ± 3.36% 0.01). Show that a small dose of zinc supplementation can improve children’s zinc nutrition status and immune function may help reduce the incidence of infectious diseases