比利时的Ｎｅｖｅｎ等根据２例对照和２项随访研究证明 ,长期应用三苯氧胺治疗的妇女 ,５０%会出现某些子宫内膜的不良反应。虽然许多妇女保留萎缩的子宫内膜层 ,但服用三苯氧胺可导致子宫内膜广泛老年性囊性萎缩、子宫内膜增生和子宫内膜息肉形成。Ｎｅｖｅｎ进行了３项研究 , According to two cases of control and two follow-up studies in Belgium, Neven et al. Demonstrated that some women with long-term use of tamoxifen experience adverse reactions of some endometrium at 50%. Although many women retain atrophic endometrial lining, taking tamoxifen leads to extensive, elderly cystic atrophy, endometrial hyperplasia and endometrial polyps in the endometrium. Neven conducted three studies,