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据推测所有妊娠胚胎的70％在最初三个月的末期死亡。遗传因素是人类生殖失败率高的主要原因。淋巴细胞培养显示平衡易位携者是伴有习惯性流产的风险增加的一种类型。对于自发性流产的胚胎的研究已经指出,染色体的异常多数是数目异常而不是结构异常,结构重排的流产的发生率仅在5％左右。非整倍体是胚胎丢失的最重要的原因,临床诊断伴三体的妊娠占第一位(50％～60％),其次是X单体(15％～25％)和多倍体(20％～25％)。
It is assumed that 70% of all pregnant embryos die at the end of the first trimester. Genetic factors is the main reason for the high rate of human reproductive failure. Lymphocyte culture shows that a balanced translocation carrier is a type of increased risk associated with habitual abortion. Studies of spontaneous abortions of embryos have indicated that the majority of chromosomal abnormalities are anomalous rather than structural abnormalities and the incidence of structural rearrangements is only about 5%. Aneuploidy is the most important cause of embryo loss. Clinical diagnosis of trisomy with pregnancy is the first (50% -60%), followed by X (15% -25%) and polyploid % ~ 25%).