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目的:观察当归对阿托品诱发小鼠便秘的治疗作用。方法:动物分为对照组、阿托品组、当归低剂量组、当归中剂量组、当归高剂量组,对照组灌胃0.4 m L生理盐水,其余各组以8 mg/kg剂量连续灌胃阿托品4 d,同时以4.8 g/kg、9.6 g/kg、14.4 g/kg剂量连续灌胃当归水煎液4 d,末次给药前12 h停食给水,当归药液、生理盐水均含10%活性炭,给药30 min后,颈椎脱臼处死各组8只小鼠,以炭末推进率、6 h时间内的排粪重量为指标,观察当归对阿托品诱导小鼠肠运动的影响。采用SPSS17.0数据分析软件,应用单因素方差分析SNK进行组间比较。结果:与阿托品组比较,当归中剂量组炭末推进率差异显著(P<0.05),高剂量组差异极显著(P<0.01);与空白组比较,6 h内阿托品组排粪数量、粒数差异不显著;与阿托品组比较,当归中剂量组、当归高剂量组排粪数量、粒数差异不显著,但有促进排粪趋势。结论:当归可以改善阿托品诱发的肠蠕动迟缓,其机制可能为解除阿托品引起的肠肌麻痹。
Objective: To observe the therapeutic effect of Angelica on atropine-induced mouse constipation. Methods: The animals were divided into the control group, the atropine group, the Chinese angelica low-dose group, the Chinese angelica medium-dose group, the Chinese angelica high-dose group, and the control group with 0.4 ml normal saline. The rest groups were treated with 8 mg / d, at the same time, the Chinese angelica decoction was continuously dosed with 4.8 g / kg, 9.6 g / kg and 14.4 g / kg for 4 days, and fed with water for 12 hours before the last administration. The angelica liquid and the physiological saline all contained 10% After administration for 30 min, 8 mice in each group were sacrificed by cervical dislocation. The effects of angelica on the gut motility induced by atropine in mice were observed by the rate of charcoal propulsion and the defecation weight in 6 hours. Using SPSS17.0 data analysis software, single-factor analysis of variance SNK for comparison between groups. Results: Compared with the atropine group, there was significant difference (P <0.05) in the rate of advancement of charcoal among the middle dose of Angelica sinensis and the high dose group (P <0.01). Compared with the blank group, The difference was not significant; compared with the atropine group, the angelica medium dose group, high dose group of Angelica, the number of fecal excretion, the difference was not significant, but to promote the trend of defecation. Conclusion: Angelica can improve atropine-induced intestinal peristalsis slow, the mechanism may be relieved of atropine-induced intestinal muscle paralysis.