论文部分内容阅读
鸟氨酸脱羧酶(ODC)是多胺合成的关键酶,ODC活性的改变可作为反映脑胶质瘤恶性程度的可靠的生物学标志;ODC基凶的诱导与恶性肿瘤的发生及其浸润性密切相关,因而具备癌基因的特性。ODC抑制剂DFMO及针对ODC的抗酶蛋白(AZ)可能对脑胶质瘤有着潜在的治疗作用。
Ornithine decarboxylase (ODC) is the key enzyme in polyamine synthesis. The change of ODC activity can be used as a reliable biomarker to reflect the malignant degree of glioma. The induction of ODC and the infiltration of malignant tumor Closely related and thus possess oncogene properties. The ODC inhibitor DFMO and anti-enzyme protein (AZ) against ODC may have a potential therapeutic effect on glioma.