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青蒿酯钠(Artesunate)对多重抗性的恶性疟原虫很有效,但其疗程较长常使病人不能完成治疗。将它与长半衰期抗疟药如甲氟喹联用,也许可使患者易于完成治疗并提高治愈率。作者对甲氟喹单用和与青蒿酯钠合用的疗效和药代动力学进行了比较。20例无并发症的成年男性急性恶性疟患者随机分为两组,一组(8例)首剂甲氟喹750mg,6h后
Artesunate is effective against multiple resistant Plasmodium falciparum but its long duration often renders the patient unable to complete treatment. It may be easier for patients to complete treatment and increase the cure rate by combining it with a long-lived anti-malarial drug such as mefloquine. The authors compared the efficacy and pharmacokinetics of mefloquine alone and in combination with artesunate sodium. Twenty patients with acute malaria without complications were randomly divided into two groups. One group (8 patients) received mefloquine 750 mg for 6 hours