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目的:探讨体外受精-胚胎移植(IVF-ET)周期中第三天移植8cell胚胎数量与临床结局的关系。方法:以2009年1月至2010年12月在本中心接受IVF-ET治疗1488个周期为研究对象。将所有移植周期按移植8cell胚胎个数分为三组,分析三组的临床妊娠率、胚胎种植率、多胎率有无差异。结果:移植两个8细胞胚胎组(C组)的临床妊娠率(59.5%)显著高于无8细胞胚胎移植组(A组)和含一个8细胞组(B组)(P<0.05),C组种植率(39.8%)显著高于其他两组,A组和移植胚胎中含一个8细胞组(B组)种植率比较有显著性差异,临床妊娠率虽无显著性差异,B组明显高于A组;多胎率分析,C组明显高于其它两组。结论:在IVF-ET周期中第3天移植8cell胚胎个数对妊娠率及种植率、多胎率有影响,在挑选胚胎时移植一个8cell胚胎搭配一个其它细胞数的胚胎能得到较好的妊娠率及有效降低多胎率。
Objective: To investigate the relationship between the number of 8cell embryos transferred on the third day of IVF-ET and clinical outcome. Methods: From January 2009 to December 2010, 1488 cycles of IVF-ET in our center were studied. All the transplantation cycles were divided into three groups according to the number of 8cell embryos transplanted. The clinical pregnancy rate, embryo implantation rate and multiple birth rate were analyzed. Results: The clinical pregnancy rate (59.5%) of the two 8-cell embryos (group C) was significantly higher than that of the group without the 8-cell embryo transfer (group A) and the group containing one 8 cell (group B) The implantation rate in group C was significantly higher than that in other two groups (39.8%). There was a significant difference in the implantation rate between group A and the group containing one 8-cell embryo (group B). The clinical pregnancy rate was not significantly different Higher than the A group; multiple fetal rate analysis, C group was significantly higher than the other two groups. CONCLUSION: The number of 8cell embryos transplanted on day 3 in IVF-ET cycle has an impact on pregnancy rate, implantation rate and multiple birth rate. When selecting embryos, one 8cell embryo transplanted with one embryo with other cells can get a better pregnancy rate And effectively reduce the multiple birth rate.