难溶药物在充分溶解和吸收入循环之前就从消化道被消除了，故生物利用度差。而一个药物的溶解速率是其固有溶解度和粒径的函数。因此降低粒度是提高溶解速率和生物利用度的有效方法。垂体前叶抑制药达那吐水溶度IOurn·mL－‘，生物利用度差。作者采用湿法球磨工艺制备达那峻纳 Poorly soluble drugs are eliminated from the digestive tract before they are fully dissolved and absorbed into the circulation, so bioavailability is poor. The dissolution rate of a drug is a function of its inherent solubility and particle size. Thus reducing particle size is an effective method to increase dissolution rate and bioavailability. Anterior pituitary inhibitory drug Na Na spit water solubility IOurn · mL- ’, poor bioavailability. The author uses wet ball milling process to prepare that satisfied Junna