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目的:研究膜联蛋白-1(Annexin-1)在精原细胞癌组织中的表达情况,探讨其临床意义。方法:应用免疫组织化学SABC法检测25例精原细胞癌组织,25例正常睾丸组织中膜联蛋白-1的表达情况,并对膜联蛋白-1表达与精原细胞癌的关系进行分析。结果:正常睾丸组织及精原细胞癌膜联蛋白-1阳性率分别为:76.00%、16.00%,膜联蛋白-1的表达与肿瘤的临床分期和肿瘤分化程度无关(P>0.05)。结论:膜联蛋白-1检测有助于提高精原细胞癌的早期诊断率。
Objective: To investigate the expression of annexin-1 in spermatogonial carcinoma and its clinical significance. Methods: The expression of annexin-1 in 25 cases of ESCC and 25 cases of normal testis was detected by immunohistochemical SABC method. The relationship between annexin-1 expression and spermatogonia was analyzed. Results: The positive rates of annexin-1 in normal testes and spermatogonial cancers were 76.00% and 16.00%, respectively. The expression of annexin-1 was not related to the clinical stage and tumor differentiation (P> 0.05). Conclusion: Annexin-1 test can help improve the early diagnosis of spermatogonia.