将阿莫西林(羟氨苄青霉素)用灭菌注射用水溶解成10mg/ml 溶液,分为若干等份后用具塞烧瓶盛装,试验选用的贮存温度从19.5℃逐渐降低至-30℃。用 HPLC 法测定含量。结果:水溶液在液态(19.5～0℃)温度范围内,t_(90)(含量降至起始值的90%所需时间)值随温度降低而递增。温度继续降至0～-7℃范围,冷冻状态药液的 t_(90)值随温度降低而递减。温度再进一步降低,药液的降解速率又逐渐减慢,直至药 The amoxicillin (amoxicillin) was dissolved in sterile water for injection 10mg / ml solution, divided into several equal parts and then filled with stoppered flask, the test storage temperature used for selection from 19.5 ℃ gradually reduced to -30 ℃. The content was determined by HPLC method. Results: In the liquid (19.5 ~ 0 ℃) temperature range, the value of t_ (90) (the content decreased to 90% of the initial value) increased with decreasing temperature. The temperature continued to drop to the range of 0 ~ -7 ℃. The value of t_ (90) in the frozen liquid decreased with decreasing temperature. Further reduce the temperature, the degradation rate of liquid medicine and gradually slow down until the medicine