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对６０ 例新生儿缺血缺氧性脑病（ＨＩＥ）患儿进行了血电解质钾、钠、氯、游离钙及阴离子间隙（ＡＧ）水平的测定，并与４０例健康儿对照组比较。结果发现ＨＩＥ组患儿血钠、血氯较正常儿低；血清游离钙水平与ＨＩＥ分度呈正相关；发现重度ＨＩＥ患儿血ＡＧ值增高，而轻中度增高不明显。考虑可能同ＨＩＥ脑部病变本身造成抗利尿激素不适当分泌释放，以及钙通道开放、钙离子内流及缺氧本身引起体内乳酸积聚等因素有关。为ＨＩＥ综合治疗中使用钙离子通道阻滞剂纠正水电解质紊乱及酸中毒时，首先需采取纠正缺氧、补充血容量、改善微循环、供给足够热量及措施提供了佐证。
The serum levels of potassium, sodium, chloride, free calcium and anion gap (AG) in 60 neonates with hypoxic-ischemic encephalopathy (HIE) were measured and compared with 40 healthy children. The results showed that children with HIE had lower blood sodium and blood chlorine than those with normal children. Serum free calcium was positively correlated with HIE grade. The values of serum AG in children with severe HIE were higher than those in normal children, but mild to moderate increases were not significant. Consideration may be associated with HIE brain lesions itself caused by the inappropriate secretion of antidiuretic hormone release, and calcium channels, calcium influx and hypoxia itself caused by the accumulation of lactic acid and other factors. For the HIE comprehensive treatment of calcium channel blockers to correct water and electrolyte disorders and acidosis, the first need to take to correct hypoxia, blood volume, improve microcirculation, provide enough calories and measures to provide evidence.