目的比较米非司酮与去氧孕烯炔雌醇片(妈富隆)对围绝经期功能失调性子宫出血的疗效。方法 76例围绝经期功能失调性子宫出血患者,随机分为米非司酮组和妈富隆组,每组38例,分别给予米非司酮和妈富隆治疗,比较两组患者的止血时间及治疗后的子宫内膜厚度,记录不良反应情况。结果妈富隆组患者的止血时间少于米非司酮组,治疗后的子宫内膜厚度小于米非司酮组,组间差异有统计学意义(P<0.05)。妈富隆组临床总有效率94.7%优于米非司酮组78.9%,组间差异有统计学意义(P<0.05),治疗期间两组患者均未见明显不良反应。结论妈富隆治疗围绝经期功血的疗效较为确切,不良反应少,安全性高,值得临床进一步推广应用。 Objective To compare the curative effect of mifepristone and desogestrel ethinyl estradiol tablets (Marvelon) on dysfunctional uterine bleeding in perimenopausal period. Methods A total of 76 patients with dysfunctional uterine bleeding in the climacteric period were randomly divided into mifepristone group and marvopolon group, with 38 patients in each group. Mifepristone and marvelon were given respectively. The bleeding time, Endometrial thickness after treatment, record adverse reactions. Results In the Marvelon group, the bleeding time was less than that in the mifepristone group, and the thickness of the endometrium after the treatment was less than that in the mifepristone group. There was significant difference between the two groups (P <0.05). The total effective rate in the Marvelon group was 94.7%, which was significantly higher than that in the mifepristone group (78.9%). There was a significant difference between the two groups (P <0.05). No adverse reactions were observed in both groups during the treatment. Conclusion Marvelon treatment of climacteric dysfunctional uterine bleeding more accurate, less adverse reactions, high safety, it is worth further clinical application.