非酒精性脂肪性肝病是一种肝组织学改变与酒精性肝病类似，但无过量饮酒史的临床病理综合征。肥胖、高脂血症、糖尿病、高血压等代谢紊乱与之发生及发展密切相关，其核心机制是胰岛素抵抗。还有一些非代谢相关因素和非酒精性脂肪性肝病的发生有关，如胰十二指肠切除术。胰十二指肠切除术是目前治疗胰头及壶腹部周围肿瘤疾病的标准术式。胰十二指肠切除术后胰腺外分泌功能减退诱发的术后营养不良与继发性非酒精性脂肪性肝病的发生和发展具有相关性。“,”Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome with similar hepatic histological changes to alcoholic liver disease, but without a history of excessive alcohol intake. Obesity, hyperlipidemia, diabetes, hypertension and other metabolic disorders are closely related to its occurrence and development, and its core mechanism is insulin resistance. In addition, there are also non-metabolic-related factors for the occurrence of non-alcoholic fatty liver disease, such as pancreatoduodenectomy. Pancreatoduodenectomy is the standard procedure for the treatment of tumor around the head of pancreas and ampulla. Postoperative pancreatic malfunction induced by pancreatic exocrine function after pancreatoduodenectomy is associated with the occurrence and development of secondary non-alcoholic fatty liver disease.