目的:警示选择性5-羟色胺再摄取抑制剂(SSRI)的不良反应。方法:汇总2001~2006年国外文献报道的SSRI致不良反应病例,并对其临床表现及安全性进行分析。结果:该类药物不良反应主要涉及生殖系统、心脑血管系统、中枢神经系统及消化系统等。结论:临床应重视该类药物的不良反应,警惕应用本品诱发严重的不良反应,特别是老人、儿童及孕妇。 Purpose: To warn of adverse effects of selective serotonin reuptake inhibitors (SSRIs). Methods: The adverse reactions of SSRIs reported in foreign literature from 2001 to 2006 were summarized and their clinical manifestations and safety were analyzed. Results: Adverse reactions of these drugs mainly related to reproductive system, cardiovascular system, central nervous system and digestive system. Conclusion: Clinical should pay attention to the adverse reactions of these drugs, vigilant application of this product induced serious adverse reactions, especially the elderly, children and pregnant women.