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目的:探讨急性冠脉综合征(ACS)患者血清单核细胞趋化蛋白-1(monocyte chemoattractantprotein-1MCP-1)变化的临床意义。方法:以ELISA法检测51例ACS患者,30例稳定型心绞痛和30例健康人血清MCP-1含量分析其与冠状动脉狭窄程度及范围的关系。结果:ACS组患者的MCP-1显著高于对照组及SAP组(P<0.01)。急性冠脉综合征患者血清MCP-1与Gensini评分无明显相关性(r=0.001 9,P=0.990 7)。结论:MCP-1可作为ACS患者的诊断敏感指标之一,但与冠状动脉病变血管狭窄程度无明显关系。
Objective: To investigate the clinical significance of the changes of monocyte chemoattractant protein-1 (MCP-1) in patients with acute coronary syndrome (ACS). Methods: The serum levels of MCP-1 in 51 patients with ACS, 30 patients with stable angina pectoris and 30 healthy individuals were detected by ELISA. The relationship between them and the degree and extent of coronary stenosis were analyzed. Results: MCP-1 in ACS group was significantly higher than that in control group and SAP group (P <0.01). There was no significant correlation between serum MCP-1 and Gensini score in patients with acute coronary syndrome (r = 0.001 9, P = 0.990 7). Conclusion: MCP-1 can be used as one of the sensitive diagnostic indexes in patients with ACS, but it has no significant relationship with the severity of coronary artery stenosis.